Podem as estatinas deter o agravamento das estenoses valvares aórticas?

Autor(es): HENRIQUE TRIA BIANCO, MARIA CRISTINA O. IZAR, FRANCISCO ANTONIO H. FONSECA

As estatinas são drogas que inibem a 3-hidroxi-3-metilglutaril coenzima A (HMG CoA) redutase. São, portanto, há muito utilizadas com o intuito principal de reduzir as taxas de colesterol de lipoproteína de baixa densidade. Entretanto, também possuem outros efeitos, ditos pleiotrópicos. Nesta revisão de dados recentes da literatura, os autores compilaram vários trabalhos publicados com a abordagem do uso desse fármaco em pacientes portadores de estenose valvar aórtica.

Descritores: estatinas; estenose da valva aórtica; calcificação.

Can statins delay the progression of the aortic stenosis?

Statins are drugs that inhibit 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, thereby blocking the synthesis of cholesterol. Since they were discovered, statins have been widely used to lower low-density lipoprotein cholesterol. However, analysis of cardiovascular research has revealed other important effects, referred to as pleiotropic effects. In this review, various aspects of the molecular pathogenesis of aortic stenosis will be summarized and connected to recent experimental and clinical studies that address the potential benefit of targeted drug therapy by statin in order to prevent the progression of the disease.

Key words: statins; aortic stenosis; calcification.